Table 2.
The values of S9, CEA, and CA19-9 alone and in combination for differential diagnosis of health donors and patients with CRC.
| Variable | AUC | Cut-off | Sensitivity | Specificity | 95% confidence interval | |
|---|---|---|---|---|---|---|
| Upper limit | Lower limit | |||||
| S9 | 0.826 | 41 | 72.94% | 81.97% | 79.15% | 86.00% |
| CEA | 0.789 | 5 | 43.96% | 96.72% | 75.13% | 82.59% |
| CA19-9 | 0.590 | 37 | 14.99% | 96.61% | 53.89% | 64.05% |
| S9 + CEA | 0.877 | 78.43% | 85.25% | 84.88% | 90.61% | |
| S9 + CA19 − 9 | 0.836 | 66.91% | 91.80% | 80.27% | 87.01% | |
| CEA + CA19 − 9 | 0.788 | 55.76% | 92.62% | 75.04% | 82.53% | |
| S9 + CEA + CA19 − 9 | 0.878 | 78.43% | 86.07% | 84.89% | 90.62% | |
S9: methylated septin 9 DNA; CEA: carcinoembryonic antigen; CA19-9: carbohydrate antigen-19-9; CRC: colorectal cancer.