Figure 1.

Cox proportional hazards model for the primary kidney outcomes and key secondary CV outcome in the FAS, with cubic B-splines of HbA_1c with three equally spaced knots stratified by region, and albuminuria and eGFR at screening. The model was fitted separately by treatment group for the primary kidney composite outcome (A) and the key secondary CV outcome (B), and with treatment interaction as a covariate for the primary kidney composite outcome (C) and the key secondary CV composite outcome (D). The reference (Ref) is mean HbA_1c (%) at baseline.