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. 2022 Jul 9;13:3989. doi: 10.1038/s41467-022-31702-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Genome browser view (IGB) comparing raw sequencing output of three different DSB capture methods used to detect induced breaks in live DIvA cells. The top panel indicates AsiSI recognition sequences present on chromosome 19. The second panel depicts the raw INDUCE-seq readout. The bottom two panels show the raw output of DSBCapture and BLISS. b Comparison between INDUCE-seq, DSBCapture and BLISS in detecting AsiSI-induced breaks in live DIvA cells. The number of reads sequenced (b, top panel) is compared to the number of AsiSI sites identified in each experiment (b, bottom panel). c AsiSI sites detected by INDUCE-seq ranked by break number. Total number of breaks were plotted at each of the 278 AsiSI restriction sites (primary y-axis). The cumulative break frequency at AsiSI sites was calculated and plotted as a percentage on the secondary y-axis. Source data are provided as a Source Data file.