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. 2022 Jul 9;13:3989. doi: 10.1038/s41467-022-31702-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a A ranked list of recurrent DSBs from the EMX1 gene-edited data. The on-target is highlighted in red, while the recurrent breaks common to both treated and untreated control sample are highlighted in blue. The recurrent breaks common to both the rank-based list and the sequence-based off-target discovery list are highlighted in green. b Sequence-based off-target discovery list. (b, left panel) On- and multiple off-target sequences and the number of breaks identified using INDUCE-seq for the EMX1 sgRNA. (b, right panel) Mismatching bases from the target sequence are highlighted and colour coded. Source data are provided as a Source Data file.