Fig. 5. Loss of PER-CK1 interaction alters circadian period length but does not abolish robust circadian behavior and other physiological rhythms.
a Locomotor activity recordings of representative mice for the WT, Per1−/−; Per2m/m and Per1−/−; Per2m/m; Per3−/− mice. Alternative white and dark bars indicate the LD cycles used for entrainment prior to release into constant darkness. See also Supplementary Fig. 4. b Average period length (±SD) quantification of the indicated mouse strains by Clocklab. The indicated p values were determined using Student’s t-test (two-sided). Error bars are standard deviations. c Circadian rhythms of oxygen consumption rate, respiratory exchange ratio and activity in the wild-type and Per1−/−; Per2m/m mice in a comprehensive lab animal monitoring system in constant darkness. n = 5 per genotype. Error bars are SEMs.