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. 2022 Jul 9;13:3993. doi: 10.1038/s41467-022-31625-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a −log₁₀P_vQTL from Levene’s test is shown for all significant index variants for each biomarker. Labels correspond to the closest gene (shown for variants with P_vQTL < 10⁻²⁰), highlighting some known GWAS loci. P values are truncated at 10⁻³⁰⁰ for visualization purposes. b Histogram displaying the number of biomarker associations for each vQTL locus. c The number of significant vQTL loci is shown for each biomarker (inset: analogous plot for main effects). Colors denote three categories: vQTL loci not shared with an ME locus (red), vQTL loci shared with an ME locus (purple), and ME loci not shared with a vQTL locus (blue).