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. 2022 Jul 9;13:3993. doi: 10.1038/s41467-022-31625-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a vQTL (red) and ME (blue) significance for rs1229984 is shown for each biomarker, based on Levene’s test and linear regression, respectively. The dashed line represents the study-wide Bonferroni vQTL significance threshold. Biomarkers with neither vQTL nor ME having p < 0.01 are not shown. b EWIS results for rs1229984 impacting ALT are shown, with GEI significance plotted (y axis) for each exposure having p < 0.05 (x axis). c Means and standard errors for ALT (n = 341,815 [CC], 17,539 [CT], 318 [TT] participants) are plotted as a function of genotype at rs1229984 (x axis) and self-reported alcohol intake (colors).