Fig. 1.

Chemical structures for UB-ALT-EV and memantine (a). Scheme of experimental design (b). Mean plasma and brain concentration − time profile of UB-ALT-EV in CD10 mice after per os administration. Inset depicts mean brain concentration − time profile of UB-ALT-EV in CD10 mice after per os administration. UB-ALT-EV (5 mg/kg; 10 mL/kg) was administered by oral gavage in mice. Data are shown as the mean ± SD (n = 3). The calculated parameters were (i) for plasma: T_max = 45 min, C_max = 1.12 ± 0.76 µM, elimination half-life = 1.5 h; (ii) brain: T_max = 56 min, C_max = 17.10 ± 6.06 µM, elimination half-life = 5 h