Fig. 2.

Results of OF: total distance (a), and entries in center zone (b). For Morris water maze: learning curve (c), representative swim paths patterns for each group (d), distance traveled in quadrants (e), distance to target of the test day (f), and entries in platform zone (g). Values are the mean ± standard error of the mean (SEM); (n = 14 for WT, n = 8 for Control, n = 11 for Mem and n = 10 for UB-ALT-EV). For WT vs. 5XFAD control groups, data were analyzed using a two-tailed Student’s t test, and for 5XFAD groups, a standard one-way ANOVA followed by Tukey post hoc analysis was performed. In the case of MWM learning curve, a repeated-measures ANOVA was performed. *p < 0.05; **p < 0.01 for WT vs. Control. ^#p < 0.05; ^##p < 0.01; for Mem or UB-ALT-EV vs. Control. For the distance in quadrants case: *p < 0.05 for Quadrant SW WT vs. Quadrant SW Control. ^#p < 0.05; ^##p < 0.01; for Quadrant SW Mem or UB-ALT-EV vs. Quadrant SW Control