Fig. 4.

Representative western blot (a) and quantifications for BACE1 (b) sAPPα (c), ratio CTFs/pre-APP (d), ratio p-GSK3β (Tyr216)/GSK3β (e), ratio AT8 p-Tau (Ser202, Th205)/Tau (f), ratio p-Tau/Tau (Ser396) (g), and Synapsin I a/b (h). Values in bar graphs are adjusted to 100% for protein levels of the wild type (WT). Values are the mean ± Standard error of the mean (SEM); (n = 3 for WT and Control groups and n = 4 for Mem and UB-ALT-EV groups. For WT vs. 5XFAD Control groups, data were analyzed using a two-tailed Student’s t test, and for 5XFAD groups, a standard one-way ANOVA followed by Tukey post hoc analysis was performed. *p < 0.05; **p < 0.01 for WT vs. Control. ^#p < 0.05; ^##p < 0.01; ^###p < 0.001 for Mem or UB-ALT-EV vs. Control