Table 3.
Estimates of change from baseline in high-density lipoprotein particle concentration
| Variable | 1 mg/d | 5 mg/d | 15 mg/d | Placebo | P, 5 mg/d vs placebo | P, any effect |
|---|---|---|---|---|---|---|
| Total HDL particle concentration, μmol/L | –0.993 (–2.31 to 0.326) | –1.99 (–3.30 to –0.688) | –0.055 (–1.32 to 1.21) | 0.210 (–1.09 to 1.51) | .0163 | .0627 |
| Extra-small HDL subspecies, μmol/L | –0.99 (–0.267 to 0.069) | –0.052 (–0.215 to 0.111) | 0.057 (–0.103 to 0.218) | 0.000 (–0.164 to 0.164) | .639 | .547 |
| Small HDL subspecies, μmol/L | –0.385 (–0.779 to 0.010) | 0.266 (–0.117 to 0.650) | 0.050 (–0.326 to 0.425) | 0.078 (–0.316 to 0.471) | .470 | .090 |
| Medium HDL subspecies, μmol/L | –0.247 (–0.850 to 0.355) | –0.966 (–1.562 to –0.370) | –0.173 (–0.755 to 0.410) | 0.215 (–0.378 to 0.807) | .005 | .038 |
| Medium-large subspecies, μmol/L | 0.012 (–0.380 to 0.404) | –0.184 (–0.555 to 0.187) | 0.101 (–0.264 to 0.465) | –0.035 (–0.405 to 0.335) | .550 | .721 |
| Large HDL subspecies, μmol/L | –0.083 (–0.635 to 0.469) | –0.832 (–1.37 to –0.289) | –0.112 (–0.637 to 0.413) | 0.060 (–0.479 to 0.599) | .017 | .075 |
| Extra-large HDL subspecies, μmol/L | –0.100 (–0.275 to 0.074) | –0.260 (–0.429 to –0.091) | –0.049 (–0.214 to 0.117) | 0.017 (–0.152 to 0.187) | .018 | .103 |
Estimated changes from baseline, 95% CIs, and P values extracted from ANCOVA framework. P values are for comparison of the 5 mg/day arm with placebo group and for the test of any difference between groups in average change over 12-week follow-up.
Abbreviations: ANCOVA, analysis of covariance; HDL, high-density lipoprotein.