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. 2022 May 23;26(2):72–82. doi: 10.4235/agmr.22.0036

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Copyright © 2022 Korean Geriatrics Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3. — Activation (right): Wnt protein binds to the LRP5/6 receptor and the Frizzled co-receptor to activate signalling pathways. With the help of protein complexes with Disheveled (Dsh), Axin, and Adenomatous Polyposis coli, this receptor complex inhibits the phosphorylation of β-catenin (APC) causing β-catenin accumulation in the cytoplasm and translocated to the nucleus. Inactivation pathway (left): sclerostin will inhibit Wnt signalling pathway causing dissociation of LRP 5/6 complex and frizzled receptor.¹⁴,²⁹,³³,³⁴) LRP, lipoprotein receptor-related protein; GSK3, glycogen synthase kinase 3; APC, adenomatous polyposis coli; Dsh, disheveled.