Table 1.
A list of actin cytoskeleton-associated genes significantly (P ≤ 0.05) upregulated by DATS treatment in the SK-BR-3 cell line
| Gene name | MCF-10A | SK-BR-3 | Gene description | |||
|---|---|---|---|---|---|---|
| Fold change | P-value | Fold change | P-value | |||
| ACKR2 | 1.24 | 0.4100 | 1.48 | 0.0135 | Atypical chemokine receptor 2 | |
| ACTB | 1.26 | 0.2035 | 1.25 | 0.0306 | Actin beta | |
| ACTBL2 | 2.49 | 0.1142 | 3.11 | 0.0062 | Actin, beta like 2 | |
| ACTR10 | 1.16 | 0.1731 | 1.26 | 0.0002 | Actin related protein 10 homolog | |
| AFAP1L1 | 1.13 | 0.1995 | 2.98 | 0.0033 | Actin filament associated protein 1 like 1 | |
| ANLN | –1.45 | 0.0188 | 1.50 | 0.0040 | Anillin actin binding protein | |
| ARHGAP21 | 1.06 | 0.4300 | 1.50 | 0.0313 | Rho GTPase activating protein 21 | |
| ARPC2 | 1.20 | 0.2129 | 1.43 | 0.0047 | Actin related protein 2/3 complex subunit 2 | |
| ASAP1 | 1.08 | 0.3273 | 1.44 | 0.0261 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | |
| BCAR1 | 1.37 | 0.0851 | 1.33 | 0.0364 | BCAR1, Cas family scaffold protein | |
| BIN1 | –1.24 | 0.0375 | 1.57 | 0.0074 | Bridging integrator 1 | |
| BIN2 | Not detected | 4.54 | 0.0042 | Bridging integrator 2 | ||
| CAP2 | 1.05 | 0.3896 | 1.30 | 0.0029 | Cyclase associated actin cytoskeleton regulatory protein 2 | |
| CAPZA2 | 1.15 | 0.1962 | 1.26 | 0.0010 | Capping actin protein of muscle Z-line subunit alpha 2 | |
| CASK | 1.06 | 0.1780 | 1.29 | 0.0281 | Calcium/calmodulin dependent serine protein kinase | |
| CD2AP | 1.05 | 0.4486 | 1.34 | 0.0332 | CD2 associated protein | |
| CDC42BPA | 1.12 | 0.0983 | 1.32 | 0.0136 | CDC42 binding protein kinase alpha | |
| CFL2 | 1.12 | 0.3922 | 1.72 | 0.0019 | Cofilin 2 | |
| CORO1C | 1.10 | 0.2186 | 1.44 | 0.0099 | Coronin 1C | |
| COTL1 | 1.22 | 0.0791 | 1.65 | 0.0102 | Coactosin like F-actin binding protein 1 | |
| CRK | 1.11 | 0.0882 | 1.24 | 0.0046 | CRK proto-oncogene, adaptor protein | |
| CRYAB | 1.74 | 0.2224 | 3.39 | 0.0476 | Crystallin alpha B | |
| CTNNA1 | 1.17 | 0.0796 | 1.26 | 0.0251 | Catenin alpha 1 | |
| CTTN | 1.17 | 0.1458 | 1.22 | 0.0478 | Cortactin | |
| DBN1 | 1.30 | 0.0556 | 1.68 | 0.0127 | Drebrin 1 | |
| DCTN6 | 1.17 | 0.2016 | 1.37 | 0.0053 | Dynactin subunit 6 | |
| EEF1A1 | 1.02 | 0.4486 | 1.18 | 0.0101 | Eukaryotic translation elongation factor 1 alpha 1 | |
| EPB41L2 | –1.03 | 0.7086 | 10.17 | 0.0362 | Erythrocyte membrane protein band 4.1 like 2 | |
| FER | –1.08 | 0.0055 | 1.55 | 0.0080 | FER tyrosine kinase | |
| FLNA | 1.04 | 0.6271 | 1.39 | 0.0427 | Filamin A | |
| GAS2L3 | –1.30 | 0.2667 | 1.84 | 0.0060 | Growth arrest specific 2 like 3 | |
| GAS7 | 1.01 | 0.9813 | 4.36 | 0.0023 | Growth arrest specific 7 | |
| GBP2 | 1.63 | 0.0703 | 1.79 | 0.0502 | Guanylate binding protein 2 | |
| GMFB | 1.00 | 0.9908 | 1.35 | 0.0180 | Glia maturation factor beta | |
| ITSN1 | 1.08 | 0.2819 | 1.71 | 0.0070 | Intersectin 1 | |
| KLHL2 | –1.03 | 0.6052 | 1.88 | 0.0196 | Kelch like family member 2 | |
| LIMA1 | 1.38 | 0.0708 | 1.67 | 0.0167 | LIM domain and actin binding 1 | |
| LIMCH1 | 1.27 | 0.0641 | 1.30 | 0.0277 | LIM and calponin homology domains 1 | |
| MICAL1 | 1.43 | 0.0692 | 1.60 | 0.0105 | Microtubule associated monooxygenase, calponin and LIM domain containing 1 | |
| MYL12A | 1.38 | 0.2107 | 1.58 | 0.0002 | Myosin light chain 12A | |
| MYL12B | 1.32 | 0.2112 | 1.50 | 0.0052 | Myosin light chain 12B | |
| MYO10 | 1.13 | 0.1758 | 1.63 | 0.0263 | Myosin X | |
| MYO7B | 1.84 | 0.0956 | 2.33 | 0.0106 | Myosin VIIB | |
| MYOM1 | –1.17 | 0.7071 | 4.96 | 0.0243 | Myomesin 1 | |
| NCKAP1 | –1.02 | 0.4588 | 1.46 | 0.0005 | NCK associated protein 1 | |
| NDC1 | –1.44 | 0.0180 | 1.27 | 0.0013 | NDC1 transmembrane nucleoporin | |
| PAWR | –1.02 | 0.6527 | 1.33 | 0.0533 | Pro-apoptotic WT1 regulator | |
| PDCD6IP | 1.12 | 0.1263 | 1.32 | 0.0080 | Programmed cell death 6 interacting protein | |
| PEAK1 | –1.03 | 0.8576 | 1.52 | 0.0068 | Pseudopodium enriched atypical kinase 1 | |
| PLS1 | 1.05 | 0.4272 | 1.62 | 0.0407 | Plastin 1 | |
| PLS3 | 1.13 | 0.1160 | 1.56 | 0.0057 | Plastin 3 | |
| RDX | –1.12 | 0.0244 | 1.38 | 0.0146 | Radixin | |
| SEPT7 | 1.04 | 0.5335 | 1.33 | 0.0197 | Septin 7 | |
| SH2B2 | 1.37 | 0.1005 | 1.54 | 0.0090 | SH2B adaptor protein 2 | |
| SPECC1 | 1.04 | 0.5224 | 1.32 | 0.0092 | Sperm antigen with calponin homology and coiled-coil domains 1 | |
| SPTA1 | Not detected | 4.03 | 0.0117 | Spectrin alpha, erythrocytic 1 | ||
| TLN2 | 1.00 | 0.9898 | 1.95 | 0.0002 | Talin 2 | |
| TMOD1 | 1.16 | 0.7239 | 4.16 | 0.0002 | Tropomodulin 1 | |
| TPM1 | 1.28 | 0.4564 | 1.69 | 0.0016 | Tropomyosin 1 | |
| TPM3 | 1.14 | 0.3401 | 1.23 | 0.0051 | Tropomyosin 3 | |
| TPM4 | 1.29 | 0.1956 | 1.37 | 0.0163 | Tropomyosin 4 | |
| TWF1 | 1.04 | 0.5886 | 1.27 | 0.0408 | Twinfilin actin binding protein 1 | |
| UTRN | 1.03 | 0.7276 | 1.35 | 0.0499 | Utrophin | |
| WDR1 | 1.29 | 0.2219 | 1.37 | 0.0064 | WD repeat domain 1 | |
| YES1 | –1.01 | 0.7511 | 1.41 | 0.0069 | YES proto-oncogene 1, Src family tyrosine kinase | |