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. 2022 May 13;7(3):100484. doi: 10.1016/j.esmoop.2022.100484

Figure 2.

Figure 2

Analyses results of baseline peripheral immune cell levels with significant association with overall survival and progression-free survival in the univariate analyses with Cox proportional hazards model.

(A) Survival curves comparing survival outcomes of patients dichotomized at the median and third quartile of each peripheral immune cell level [CD14+CD11c+HLA-DR+ monocyte and progression-free survival (left, top; quartile 1-3 versus quartile 4, P = 0.1031), CD14+CD11c+HLA-DR+ monocyte and overall survival (right, top; quartile 1-3 versus quartile 4, P = 0.0448), Foxp3+CD4+ regulatory T cell and progression-free survival (left, bottom; median, P = 0.0234) and Foxp3+CD4+ regulatory T cell and overall survival (right, bottom; median, P = 0.1787)]. (B) Forest plot showing multivariate Cox proportional hazards modeling results with baseline peripheral immune cell levels with significant association in the univariate analyses and clinical characteristics [top; progression-free survival, R0 resection (HR 0.26, 95% CI 0.10-0.67, P = 0.006) and Foxp3+CD4+ T cell (HR 0.89, 95% CI 0.77-1.03, P = 0.123), bottom; overall survival, R0 resection (HR 0.11, 95% CI 0.02-0.44, P = 0.003) and CD14+CD11c+HLA-DR+ monocyte (HR 1.06, 95% CI 1.00-1.13, P = 0.043)].

CI, confidence interval; HLA, human leukocyte antigen; HR, hazard ratio; OS, overall survival; PFS, progression-free survival.