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. 2022 May 13;7(3):100484. doi: 10.1016/j.esmoop.2022.100484

Figure 3.

Figure 3

Changes in peripheral T-cell checkpoint expression after eight cycles of preoperative chemotherapy.

(A) Paired comparisons of the proportion of PD-1+CD8+ T cells (left; median difference = −3.22%, P = 0.0110) and TIGIT+CD4+ T cells (right; median difference = −0.84%, P = 0.0701) at baseline and after eight cycles of mFOLFIRINOX. (B) Flow cytometry dot plots comparing the proportion of checkpoint-expressing T cells (left, PD-1+CD8+ T cells; rights, TIGIT+CD4+ T cells). ∗P < 0.10.

mFOLFIRINOX, modified folinic acid, fluorouracil, irinotecan hydrochloride, oxaliplatin; PD-1, programmed cell death protein 1.