Figure 5.

Comparison of immune cells in the tumor microenvironment according to the recurrence group (DFS10 achieved versus DFS10 failed).

(A) Comparison of CD8+ T-cell infiltration in the peritumoral region (left, P = 0.0145) and the total region (right, P = 0.1215). (B) Representative histopathologic and immunostained slides comparing CD8+ T-cell infiltration between the two groups (left: DFS10 achieved; right: DFS10 failed). A greater number of CD8+ cells (red staining) infiltration seen within the peritumoral region (marked with red line) in the DFS10 achieved group (left) compared with the DFS10 failed group (right). (C) Immune cell score estimated using the Nanostring annotation. CD8+ cell score (top left, P = 0.1259), cytotoxic cell score (top right, P = 0.3283), T-cell score (bottom left, P = 0.2109), and exhausted CD8+ T-cell score (bottom right, P = 0.2854).

DFS, disease-free survival.