Table 3.
Multivariable logistic regression of factors associated with enrolment in clinical trials (N = 9516)
| Effect | Adjusteda OR | 95% Confidence intervals | P value | |
|---|---|---|---|---|
| Age <40 versus >65 | 0.96 | 0.70 | 1.31 | 0.7902 |
| Age 40-50 versus >65 | 0.79 | 0.64 | 0.98 | 0.0300 |
| Age 50-65 versus >65 | 0.75 | 0.63 | 0.90 | 0.0021 |
| BMI ≥25 versus <25 | 1.05 | 0.91 | 1.21 | 0.5268 |
| Charlson ≥1 versus 0 | 1.09 | 0.91 | 1.29 | 0.3527 |
| Depression normal versus doubtful case/case | 1.00 | 0.83 | 1.21 | 0.9994 |
| Anxiety normal versus doubtful case/case | 1.17 | 1.01 | 1.35 | 0.0363 |
| Relationship no versus yes | 0.98 | 0.80 | 1.19 | 0.8295 |
| Children no versus yes | 1.13 | 0.79 | 1.60 | 0.5068 |
| BC familiar history negative versus positive | 0.99 | 0.84 | 1.17 | 0.9134 |
| Previous cancer no versus yes | 1.09 | 0.82 | 1.44 | 0.5395 |
| Previous breast surgery no versus yes | 1.18 | 0.89 | 1.56 | 0.2421 |
| High school versus primary school | 1.13 | 0.90 | 1.42 | 0.3031 |
| College or higher versus primary school | 1.09 | 0.82 | 1.44 | 0.5580 |
| Income <2000 versus 2000-4000 | 0.91 | 0.75 | 1.09 | 0.3045 |
| Income >4000 versus 2000-4000 | 0.92 | 0.77 | 1.10 | 0.3761 |
| Middle-class workers versus executives, managers | 1.04 | 0.86 | 1.24 | 0.6899 |
| Unemployed, retired, versus executives, managers | 1.49 | 0.89 | 2.49 | 0.1281 |
| Manual workers and self employed versus executive, managers | 1.04 | 0.82 | 1.32 | 0.7409 |
| Residency centre/north versus Ile de France | 1.26 | 1.05 | 1.51 | 0.0145 |
| Residency south versus Ile de France | 1.51 | 1.20 | 1.89 | 0.0004 |
| Centre volume intermediate (200-1000) versus low (<200) | 1.45 | 1.08 | 1.95 | 0.0124 |
| Centre volume high (>1000) versus low (<200) | 1.17 | 0.84 | 1.63 | 0.3597 |
| Different region versus same region between residence and centre of care | 0.98 | 0.77 | 1.23 | 0.8365 |
| Stage II versus stage I | 1.56 | 1.33 | 1.84 | <0.0001 |
| Stage III versus stage I | 1.32 | 1.01 | 1.73 | 0.0451 |
| Chemotherapy yes versus no | 1.12 | 0.94 | 1.33 | 0.2167 |
| Conservative surgery versus mastectomy | 1.07 | 0.89 | 1.28 | 0.4740 |
| Hormone therapy yes versus no | 1.34 | 1.11 | 1.62 | 0.0021 |
| Radiotherapy yes versus no | 1.98 | 1.43 | 2.76 | <0.0001 |
| Anti-HER2 therapy yes versus no | 1.14 | 0.92 | 1.40 | 0.2286 |
BC, breast cancer; BMI, body mass index; HER2, human epidermal growth factor receptor 2; OR, odds ratio.
a
Adjusted for all factors in the table, including year of breast cancer diagnosis.