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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: J Allergy Clin Immunol. 2022 Jan 24;150(1):114–130. doi: 10.1016/j.jaci.2021.12.794

Figure 8. Co-delivery of hapten and NK1R antagonists in the skin desensitizes CD locally and systemically in hapten-specific fashion.

Figure 8.

A) Timeline describing the experiments of induction and desensitization of CHS in mice. B and C) Reduction of established CHS in mice, treated with MNA on day 22 and re-challenged on day 29, with topical DNCB on the treated homolateral (right) ear (B), or on the contralateral (left) ear (C). D) Mice with established skin CHS to oxazolone, treated with DNBS-NK1Rantagonist-MNA on the homolateral (right) ear on day 22 and re-challenged with topical oxazolone on the same ear on day 29. In (B), (C) and (D), a representative experiment of 3 is shown. Five mice per group. Each dot represents one mouse. Means ± 1 SD were analyzed by 1-way ANOVA followed by Student-Newman-Keuls test. **p < 0.01, ***p < 0.001, ****p < 0.0001. NS: not significant.