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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: J Allergy Clin Immunol Pract. 2022 Jan 29;10(7):1903–1906. doi: 10.1016/j.jaip.2022.01.012

Figure 1. TGF-β signaling and ERBIN regulation.

Figure 1.

TGF-β activates SMAD3, which translocates into the nucleus to promote Th2 skewing of lymphocyte responses. The STAT3-ERBIN complex negatively regulates TGF-β signaling by sequestering cytoplasmic SMAD3. The ERBB2IP variant (c.1588G>T [p.D530Y]) impairs STAT3-ERBIN-SMAD2/3 complex formation, increasing TGF-β signaling through SMAD3. Dupilumab targets IL-4Rα and can block IL-4–mediated effects of dysregulated TGF-β signaling. P, phosphorylation