Table 2:
Retinal and choroidal imaging parameters of all subjects at baseline
| Parameters | APOE ε4+ N=186 eyes (98 subjects) |
APOE ε4− N=227 eyes (120 subjects) |
P-valuea |
|---|---|---|---|
| OCT parameters, mean (SD) | |||
| Average CST, microns | 263.0 (22.0) | 268.8 (24.8) | 0.018 |
| Average GC-IPL thickness, microns | 75.59 (7.35) | 75.65 (6.93) | 0.784 |
| Average RNFL thickness, microns | 88.42 (9.38) | 87.70 (9.12) | 0.806 |
| Choroidal parameters, mean (SD) | |||
| Total choroidal area, units2 b | 4.67 (1.02) | 4.69 (1.10) | 0.367 |
| Luminal area, units2 b | 3.18 (0.67) | 3.20 (0.73) | 0.337 |
| Choroidal vascularity index, % | 0.68 (0.02) | 0.68 (0.02) | 0.847 |
| OCTA parameters, mean (SD) | |||
| FAZ area, mm2 | 0.25 (0.10) | 0.24 (0.10) | 0.764 |
| PD (3mm ETDRS circle) | 0.36 (0.03) | 0.36 (0.03) | 0.252 |
| PD (3mm ETDRS ring) | 0.38 (0.03 | 0.38 (0.02) | 0.341 |
| VD (3mm ETDRS circle), mm−1 | 19.91 (1.62) | 20.06 (1.58) | 0.228 |
| VD (3mm ETDRS ring), mm−1 | 20.99 (1.64) | 21.10 (1.57) | 0.301 |
| PD (6mm ETDRS circle) | 0.43 (0.03) | 0.44 (0.03) | 0.049 |
| PD (6mm ETDRS outer ring) | 0.44 (0.03) | 0.45 (0.03) | 0.099 |
| PD (6mm ETDRS inner ring) | 0.43 (0.04) | 0.43 (0.03) | 0.076 |
| VD (6mm ETDRS circle), mm−1 | 17.74 (1.28) | 17.89 (1.11) | 0.114 |
| VD (6mm ETDRS outer ring), mm−1 | 17.98 (1.28) | 18.11 (1.20) | 0.183 |
| VD (6mm ETDRS inner ring), mm−1 | 17.89 (1.40) | 18.07 (1.14) | 0.111 |
| Peripapillary OCTA parameters, mean (SD) | |||
| CPD (average), % | 43.50 (2.09) | 43.44 (2.04) | 0.994 |
| CPD (superior), % | 42.05 (2.96) | 42.26 (2.79) | 0.444 |
| CPD (nasal), % | 42.14 (2.90) | 42.31 (2.86) | 0.506 |
| CPD (inferior), % | 44.34 (3.18) | 43.96 (2.88) | 0.514 |
| CPD (temporal), % | 45.57 (3.13) | 45.39 (2.90) | 0.657 |
| CFI (average) | 0.40 (0.04) | 0.41 (0.04) | 0.135 |
| CFI (superior) | 0.40 (0.04) | 0.41 (0.03) | 0.180 |
| CFI (nasal) | 0.40 (0.04) | 0.41 (0.03) | 0.224 |
| CFI (inferior) | 0.41 (0.04) | 0.41 (0.03) | 0.402 |
| CFI (temporal) | 0.39 (0.06) | 0.41 (0.06) | 0.047 |
CST=central subfield thickness, GC-IPL=ganglion cell-inner plexiform layer, RNFL=retinal nerve fiber layer, FAZ=foveal avascular zone, PD=perfusion density, VD=vessel density, ETDRS=Early Treatment Diabetic Retinopathy Study, CPD=capillary perfusion density, CFI=capillary flux index.
a
P-values based on generalized estimating equations (GEE) model score statistic for testing difference among and between means. P-values from GEE model adjusted for sex and age.
b
Units2= 96×96 pixels2