Table 4:
Within-group retinal and choroidal imaging parameters of subjects imaged longitudinally
| Parameters | APOE ε4+ N=71 patients (134 eyes) |
APOE ε4− N=78 patients (149 eyes) |
||
|---|---|---|---|---|
| Mean change (SD) | P-valueb | Mean change (SD) | P-valueb | |
| OCT parameters | ||||
| Average CST, microns | −0.133 (5.635) | 0.748 | −1.384 (5.262) | 0.015 |
| Average GC-IPL thickness, microns | −0.292 (2.712) | 0.265 | 0.224 (2.454) | 0.413 |
| Average RNFL thickness, microns | 0.223 (3.221) | 0.464 | 0.466 (3.701) | 0.163 |
| Choroidal parameters | ||||
| Total choroidal area, units2 c | 0.083 (0.544) | 0.144 | −0.025 (0.518) | 0.696 |
| Luminal area, units2 c | 0.048 (0.352) | 0.176 | −0.020 (0.328) | 0.594 |
| Choroidal vascularity index, % | −0.001 (0.013) | 0.428 | > −0.001 (0.013) | 0.808 |
| OCTA parameters | ||||
| FAZ area, mm2 | 0.006 (0.023) | 0.010 | 0.004 (0.031) | 0.175 |
| PD (3mm ETDRS circle) | 0.002 (0.028) | 0.746 | 0.004 (0.031) | 0.204 |
| PD (3mm ETDRS ring) | 0.002 (0.027) | 0.580 | 0.004 (0.031) | 0.182 |
| VD (3mm ETDRS circle), mm−1 | −0.122 (1.580) | 0.353 | −0.058 (1.825) | 0.805 |
| VD (3mm ETDRS ring), mm−1 | −0.105 (1.597) | 0.415 | −0.045 (1.884) | 0.880 |
| PD (6mm ETDRS circle) | −0.004 (0.036) | 0.265 | −0.002 (0.034) | 0.614 |
| PD (6mm ETDRS outer ring) | −0.005 (0.035) | 0.117 | −0.002 (0.035) | 0.664 |
| PD (6mm ETDRS inner ring) | > −0.001 (0.044) | 0.926 | > 0.001 (0.039) | 0.961 |
| VD (6mm ETDRS circle), mm−1 | −0.217 (1.344) | 0.082 | −0.162 (1.298) | 0.221 |
| VD (6mm ETDRS outer ring), mm−1 | −0.253 (1.304) | 0.039 | −0.163 (1.345) | 0.246 |
| VD (6mm ETDRS inner ring), mm−1 | −0.111 (1.682) | 0.461 | −0.135 (1.501) | 0.329 |
| Peripapillary OCTA parameters | ||||
| CPD (average), % | −0.454 (1.235) | <0.001 | −0.284 (1.257) | 0.018 |
| CPD (superior), % | −0.016 (1.865) | 0.935 | −0.003 (1.788) | 0.966 |
| CPD (nasal), % | −0.880 (2.404) | <0.001 | −0.516 (2.054) | 0.011 |
| CPD (inferior), % | 0.354 (1.855) | 0.049 | 0.435 (1.639) | 0.010 |
| CPD (temporal), % | −1.065 (1.860) | <0.001 | −0.932 (2.060) | <0.001 |
| CFI (average) | −0.031 (0.045) | <0.001 | −0.020 (0.040) | <0.001 |
| CFI (superior) | −0.015 (0.035) | <0.001 | −0.010 (0.028) | <0.001 |
| CFI (nasal) | −0.042 (0.061) | <0.001 | −0.031 (0.056) | <0.001 |
| CFI (inferior) | −0.014 (0.030) | <0.001 | −0.006 (0.028) | 0.023 |
| CFI (temporal) | −0.051 (0.065) | <0.001 | −0.031 (0.061) | <0.001 |
CST=central subfield thickness, GC-IPL=ganglion cell-inner plexiform layer, RNFL=retinal nerve fiber layer, FAZ=foveal avascular zone, PD=perfusion density, VD=vessel density, ETDRS=Early Treatment Diabetic Retinopathy Study, CPD=capillary perfusion density, CFI=capillary flux index.
a
Note: baseline data only those for subjects were participated in 2-year follow-up imaging
b
P-values based on generalized estimating equations (GEE) model score statistic for testing differences among and between means. P-values from GEE model adjusted for sex and age.
c
Unit2= 96×96 pixels2