Table 6:
Rate of change in retinal and choroidal imaging parameters
| APOE ε4+ N=134 eyes (71 subjects) |
APOE ε4− N=149 eyes (78 subjects) |
P-valuea | |||
|---|---|---|---|---|---|
| Mean change per year (SD) |
Equivalent % change/year |
Mean change per year (SD) |
Equivalent % change/year |
||
| OCT parameters | |||||
| Average CST, microns | −0.138 (3.107) | −0.05% | −0.657 (2.585) | −0.24% | 0.325 |
| Average GC-IPL thickness, microns | −0.158 (1.332) | −0.21% | 0.128 (1.219) | 0.17% | 0.099 |
| Average RNFL thickness, microns | 0.104 (1.571) | 0.12% | 0.250 (1.815) | 0.29% | 0.420 |
| Choroidal parameters | |||||
| Total choroidal area, units2 b | 0.023 (0.254) | 0.48% | −0.024 (0.250) | −0.51% | 0.303 |
| Luminal area, units2 b | 0.013 (0.164) | 0.40% | −0.017 (0.159) | −0.53% | 0.287 |
| Choroidal vascularity index, % | < −0.0005 (0.006) | < −0.07% | < −0.0005 (0.007) | < −0.09% | 0.874 |
| OCTA parameters | |||||
| FAZ area, mm2 | 0.003 (0.016) | 1.25% | 0.002 (0.164) | 0.87% | 0.722 |
| PD (3mm ETDRS circle) | 0.002 (0.016) | 0.56% | 0.002 (0.015) | 0.56% | 0.916 |
| PD (3mm ETDRS ring) | 0.002 (0.016) | 0.53% | 0.002 (0.015) | 0.53% | 0.955 |
| VD (3mm ETDRS circle), mm−1 | 0.012 (0.910) | 0.06% | 0.006 (0.876) | 0.03% | 0.907 |
| VD (3mm ETDRS ring), mm−1 | 0.023 (0.939) | 0.11% | 0.014 (0.903) | 0.07% | 0.907 |
| PD (6mm ETDRS circle) | −0.001 (0.018) | −0.23% | < −0.0005 (0.015) | < −0.11% | 0.723 |
| PD (6mm ETDRS outer ring) | −0.002 (0.017) | −0.44% | < −0.0005 (0.016) | < −0.11% | 0.406 |
| PD (6mm ETDRS inner ring) | 0.001 (0.024) | 0.23% | 0.001 (0.018) | 0.23% | 0.784 |
| VD (6mm ETDRS circle), mm−1 | −0.070 (0.677) | −0.39% | −0.054 (0.599) | −0.30% | 0.782 |
| VD (6mm ETDRS outer ring), mm−1 | −0.095 (0.637) | −0.53% | −0.054 (0.625) | −0.30% | 0.525 |
| VD (6mm ETDRS inner ring), mm−1 | −0.002 (0.919) | −0.01% | −0.048 (0.704) | −0.26% | 0.644 |
| Peripapillary OCTA parameters, mean (SD) | |||||
| CPD (average), % | −0.193 (0.679) | −0.44% | −0.149 (0.593) | −0.34% | 0.855 |
| CPD (superior), % | 0.028 (1.026) | 0.07% | 0.002 (0.833) | 0.00% | 0.505 |
| CPD (nasal), % | −0.390 (1.162) | −0.92% | −0.277 (0.993) | −0.65% | 0.637 |
| CPD (inferior), % | 0.176 (0.913) | 0.39% | 0.211 (0.797) | 0.48% | 0.758 |
| CPD (temporal), % | −0.486 (0.881) | −1.07% | −0.473 (0.986) | −1.04% | 0.884 |
| CFI (average) | −0.015 (0.021) | −3.75% | −0.010 (0.020) | −2.44% | 0.305 |
| CFI (superior) | −0.007 (0.016) | −1.71% | −0.005 (0.014) | −1.22% | 0.573 |
| CFI (nasal) | −0.020 (0.028) | −5.13% | −0.015 (0.027) | −3.75% | 0.552 |
| CFI (inferior) | −0.007 (0.014) | −1.71% | −0.003 (0.013) | −0.71% | 0.211 |
| CFI (temporal) | −0.024 (0.030) | −6.00% | −0.015 (0.030) | −3.57% | 0.161 |
CST=central subfield thickness, GC-IPL=ganglion cell-inner plexiform layer, RNFL=retinal nerve fiber layer, FAZ=foveal avascular zone, PD=perfusion density, VD=vessel density, ETDRS=Early Treatment Diabetic Retinopathy Study, CPD=capillary perfusion density, CFI=capillary flux index.
a
P-values based on generalized estimating equations (GEE) model score statistic for testing differences among and between means. P-values from GEE model adjusted for sex and age.
b
Unit2= 96×96 pixels2