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. Author manuscript; available in PMC: 2023 Jul 7.
Published in final edited form as: Structure. 2022 Apr 29;30(7):993–1003.e6. doi: 10.1016/j.str.2022.04.003

Figure 3. Antibody 1D12 appears to be a unique class.

Figure 3.

(A) Workflow for determination of 1D12 antibody as a new influenza antibody class. (B) Classification of influenza antibodies encoded by either HV1–2 or KV2–28 from published papers and this paper. (C) - (E) Superposition of 1D12-HA complex with modeled HA complex structures of 315–27-1C08, 315–02-1A05 and 1000–3D04 showing their predicted binding interactions at CDR H3 (left panel of each set) and CDR L1 (right panel of each set). Interacting residues are shown in stick representation. (F) HA binding analysis of antibodies 1D12, 315–02-1A05, and 315–27-1C08, and their heavy and light chain-swapped variants by biolayer interferometry using Octet RED.(G) Summary of classification of 1D12 class antibody. See also Figure S3.