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. 2022 Jun 27;13:890029. doi: 10.3389/fendo.2022.890029

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Copyright © 2022 Zhang, Xiao, Liu, He, Cui, Tang, Li and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Associations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) with coronary heart disease (CHD) in men with type 2 diabetes mellitus. Restricted cubic splines were used to assess the dose–response associations of DHEA (A) and DHEAS (B) with CHD after adjusting for age, current smoking, current drinking, insurance type, body mass index (BMI), duration of diabetes, systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), and the use of glucagon-like peptide 1 (GLP-1) receptor agonists or sodium–glucose cotransporter 2 (SGLT-2) inhibitors. The p-values for nonlinear associations were 0.969 and 0.942 for DHEA and DHEAS, respectively.