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. 2022 Jun 27;13:922825. doi: 10.3389/fendo.2022.922825

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Copyright © 2022 Pablos, Casanueva-Álvarez, González-Casimiro, Merino, Perdomo and Cózar-Castellano

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ciliary insulin/IGF-1 signaling pathways. (A) Insulin stimulates resorption of cilia mouse in 3T3-L1 cells through activation of IGF-1R via recruitment of IRS1. Activated IRS1 is re-localized to the ciliary neck region, where heat shock protein Hsp90α might functions as a hub for activation of AKT. (B) Ciliary insulin growth factor-1 receptor (IGF-1R) activation induces ciliary resorption and G1/S progression via IGF-1-mediated recruitment of phosphorylated Tctex-type 1 (TCTEX-1) via non-canonical G-protein signaling (Cβγ) in RPE-1 cells. This figure was created using Servier Medical Art (available at https://smart.servier.com/).