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. 2022 Jul 6;15:3537–3548. doi: 10.2147/IDR.S371248

Table 5.

Antibiotics Susceptibility Pattern of Carbapenem-Resistant K. pneumoniae Isolates to New Antibiotics According to Their Carbapenemase Genes (n=52)

Antibiotic
Carbapenemase Gene
CZA C/T FDC
S I R S I R S I R
N N N N N N N N N
(%) (%) (%) (%) (%) (%) (%) (%) (%)
CR Klebsiella (52): 11 - 41 0 0 52 50 2 0
21 - 79 0.0 0.0 100 96 4 0.0
- Carbapenemase genes negative (n=10) 5 - 5 0 0 10 10 0 0
50 - 50 0.0 0.0 100 100 0.0 0.0
- Carbapenemase genes positive (n=42) 6 - 36 0 0 42 40 2 0
14.3 - 85.7 0.0 0.0 100 95.2 4.8 0.0
 ● Class B MBL (blaNDM) positive (n=17) 0 - 17 0 0 17 17 0 0
0.0 - 100 0.0 0.0 100 100 0.0 0.0
 ● Class A (blaKPC) positive (n=6) 2 - 4 0 0 6 6 0 0
33.3 - 66.7 0.0 0.0 100 100 0.0 0.0
 ● Class D (blaOXA-48) positive (n=10) 4 - 6 0 0 10 10 0 0
40 - 60 0.0 0.0 100 100 0.0 0.0
 ● Both blaNDM+ OXA-48 positive (n=9) 0 - 9 0 0 9 7 2 0
0.0 - 100 0.0 0.0 100 77.7 22.2 0.0

Abbreviations: CZA, ceftazidime–avibactam; C/T, ceftolozane–tazobactam; FDC, cefiderocol.