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. 2022 Jun 27;15:932939. doi: 10.3389/fnmol.2022.932939

FIGURE 5.

FIGURE 5

SB216763 treatment 6 h after retrieval does not affect the heroin seeking in the following cue-induced and heroin-primed reinstatement. (A) Timeline of heroin self-administration, nosepoke extinction, cue-induced reinstatement test and drug-induced reinstatement test. (B) Total number of heroin infusions during acquisition of heroin self-administration. (C) Total number of active nosepoke responses during extinction training sessions. (D,F) Active (left) and inactive (right) nosepoke responses during the last extinction training session and the cue-induced reinstatement test. (D) Nosepoke responses of rats with BLA drug injection. (F) Nosepoke responses of rats with CeA drug injection. (E,G) Active (left) and inactive (right) nosepoke responses across the saline- or heroin- primed reinstatement test. (E) Nosepoke responses of rats with BLA drug injection. (G) Nosepoke responses of rats with CeA drug injection. n = 9–10 mice per group. Data are means ± SEM. CS, conditioned stimulus; Ext, extinction; Reinst, reinstatement.