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. 2022 Jun 27;13:829057. doi: 10.3389/fimmu.2022.829057

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Copyright © 2022 Chen, Wang, Wang, Gui and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The heat map of immune-related DEGs in LUAD. (B) Volcano map of immune-related DEGs in LUAD. Green, downregulated genes; red, upregulated genes. (C) Venn diagram of the intersection genes related to both mRNAsi and immunity. (D) Univariate COX regression analysis of prognosis-related stem cell and immune-related differential genes (SCIRGs) in LUAD. (E, F) Kaplan–Meier curves show a considerable difference between the high- and the low-risk groups. (G) Heat maps of the hub genes’ expression pattern, where the red to green means changes from high to low expression in TCGA. (H) Distribution of multi-genes signature risk score in TCGA datasets. (I) The survival status and interval of TCGA-LUAD patients.