TABLE 3.
Comparison of genotypes and allele distribution frequencies between the SIL group and its subgroups with the healthy control group.
| Genotype and allele | Control | Case | P | OR [95% CI] | Statistical model | P′ | P′′ | OR [95% CI] |
|---|---|---|---|---|---|---|---|---|
| Control (n= 495) | SIL (n = 775) | |||||||
| AA | 259 (52.3%) | 351 (45.3%) | Dominant | 0.0213 | 0.0228 | 0.764[0.607–0.961] | ||
| AG | 189 (38.2%) | 337 (43.5%) | Recessive | 0.1861 | 0.1881 | 0.773[0.528–1.132] | ||
| GG | 47 (9.49%) | 87 (11.2%) | 0.0493 | Additive | 0.0199 | 0.0208 | 0.814[0.684–0.968] | |
| A | 707 (71.4%) | 1,039 (67.0%) | ||||||
| G | 283 (28.6%) | 511 (33.0%) | 0.0202 | 0.814[0.684–0.968] | ||||
| Control (n= 495) | HSIL (n = 619) | |||||||
| AA | 259 (52.3%) | 283 (45.7%) | Dominant | 0.0356 | 0.0366 | 0.773[0.608–0.983] | ||
| AG | 189 (38.2%) | 270 (43.6%) | Recessive | 0.3067 | 0.3102 | 0.811[0.543–1.211] | ||
| GG | 47 (9.49%) | 66 (10.7%) | 0.0903 | Additive | 0.0406 | 0.0401 | 0.827[0.689–0.992] | |
| A | 707 (71.4%) | 836 (67.5%) | ||||||
| G | 283 (28.6%) | 402 (32.5%) | 0.0483 | 0.832[0.694–0.999] | ||||
| Control (n= 495) | LSIL (n = 156) | |||||||
| AA | 259 (52.3%) | 68 (43.6%) | Dominant | 0.0631 | 0.0633 | 0.702[0.484–1.019] | ||
| AG | 189 (38.2%) | 67 (42.9%) | Recessive | 0.0928 | 0.0916 | 0.614[0.348–1.084] | ||
| GG | 47 (9.49%) | 21 (13.5%) | 0.1180 | Additive | 0.0308 | 0.0327 | 0.740[0.564–0.973] | |
| A | 707 (71.4%) | 203 (65.1%) | ||||||
| G | 283 (28.6%) | 109 (34.9%) | 0.0330 | 0.745[0.569–0.977] |
SIL, cervical squamous intraepithelial lesion; HSIL, high-grade cervical squamous intraepithelial lesion; LSIL, low-grade cervical squamous intraepithelial lesion; OR, odds ratio; CI, confidence interval.
P: p-value (control vs. SIL; control vs. HSIL; control vs. LSIL ); p values <0.05 are considered statistically significant, and shown in bold.
P’: age was adjusted.
P”: the p-value was calculated using 10,000 permutations for each model to correct the multiple tests.