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. 2022 Jun 27;13:910582. doi: 10.3389/fimmu.2022.910582

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Copyright © 2022 Weng, Liu, Xu, Ge, Ren, Dang, Liu, Zhang, Luo, Ren and Han

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The identification and prognostic value assessment of ALXO12. (A, B) GO (A) and KEGG (B) enrichment analysis results of bevacizumab-related genes. (C) Bevacizumab-related genes with AUC >0.70. (D) Validation of the correlation between six-hub genes and bevacizumab response in four external cohorts and our internal cohort. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. (E) Kaplan–Meier survival analysis of the high and low ALOX12 expression groups in TCGA-CRC and GSE72970. (F) Multivariate Cox regression analysis of OS, RFS, and PFS in TCGA-CRC, GSE72970, and our cohort. ns, no significance.