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. 2022 Jun 27;13:910582. doi: 10.3389/fimmu.2022.910582

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Copyright © 2022 Weng, Liu, Xu, Ge, Ren, Dang, Liu, Zhang, Luo, Ren and Han

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of ALOX12-related mutation and copy number variation driver targets. (A) The mutational landscape of the top 30 frequently mutated genes (FMGs). (B) The mutation frequency of 30 FMGs between the high and low ALOX12 expression groups. (C) Boxplot of TMB, SNP, and INDEL between the high- and low-risk groups. (D) Identification of ALOX12 expression-related mutations. (E) Determination of independent ALOX12 expression-related gene mutation through univariate and multivariate logistic regression analyses. (F) The CNV landscape of the top 15 AMP and Homdel chromosome fragments between two ALOX12 expression groups. (G) Identification of ALOX12 expression-related CNV chromosome segments. (H) Determination of independent ALOX12 expression-related CNV chromosome segment through univariate and multivariate logistic regression analyses. *P < 0.05, **P < 0.01, ***P < 0.001. ns, no significance.