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. 2022 Jun 27;13:951831. doi: 10.3389/fphar.2022.951831

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Copyright © 2022 Mao, Xu, Jiang, Sun, Sun, Yang, Chai, Li, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective effect of the SNM on cells isolated from the peripheral blood lymphocytes of healthy volunteers. Peripheral-blood lymphocytes were isolated from blood donated from healthy volunteers. T cells (A,D), B cells (B,E), and NK cells (C,F) were obtained by sorting. T cells (A,D), B cells (B,E), or NK cells (C,F) were treated with immunotoxic drugs (sorafenib, cabozantinib, regorafenib, and lenvatinib at 1 μmol/L; paclitaxel (300 nmol/L), etoposide, (300 nmol/L), CCCP ((300 nmol/L), and adriamycin (100 nmol/L) alone or in combination with the SNM. Then, the MTT assay (A–C), or apoptosis (D–F) assay were conducted to determine the damage wrought by these drugs on T cells (A,D), B cells (B,E), or NK cells (C,F). The results are shown as heatmaps.