TABLE 3.

The single nucleotide mixture can down-regulate the IC ₅₀ value of a series of concentrations of sorafenib or BMS-1166 in HCC cells.

Cell lines	Groups	Sorafenib	BMS-1166
		IC 50 values (mg/kg)
MHCC97-H	tumor volumes	0.52 ± 0.27	2.59 ± 0.50
	tumor weights	0.11 ± 0.05	0.75 ± 0.38
H22	tumor volumes	3.84 ± 0.79	5.66 ± 0.67
	tumor weights	1.04 ± 0.61	0.64 ± 0.48

Table notes: H22 cells were still inoculated into BalB/c mice, and after MHCC97-H cells were inoculated into SCID mice, the SCID mice were infused with healthy human-derived peripheral blood lymphocytes (1 × 10⁷ cells for each time and perfumed time times). The concentrations of sorafenib: 3, 2, 1, 0.5, 0.2, 0.1 mg/kg in SCID mice and 10, 5, 2, 1, 0.5, 0.2 mg/kg in BalB/c mice; BMS-1166: 10, 5, 2, 1, 0.5, 0.2 mg/kg in SCID mice and 20, 10, 5, 2, 1, 0.5 mg/kg in BalB/c mice.