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Simulated pharmacokinetic parameters of TIZ in human and hamster at steady state.
Predicted steady-state pharmacokinetic parameters of TIZ, i.e. Cmax (A), AUC (B) and Cmin (C), in human associated with receiving 1000mg/day BID of NTZ (grey box) were compared with pharmacokinetic parameters of hamster receiving 50, 100, 200, 500 and 1000mg/kg/day BID of NTZ (colored boxes). Boxes and whiskers represent the median with inter-quantile range and the 95% prediction intervals, respectively.
