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Simulated pharmacokinetic parameters derived from nonlinear mixed-effect modelling using population mean values and median body weight of 0.126kg.
| NTZ dose (mg/kg) | Cmax (μg/ml) | AUC0-24h (µg·h/ml) |
|---|---|---|
| 25.0 | 3.14 | 4.18 |
| 50.0 | 6.27 | 8.36 |
| 100 | 12.5 | 16.7 |
| 125 | 15.7 | 20.9 |
| 250 | 31.4 | 41.8 |
| 500 | 62.7 | 83.6 |
Cmax: maximum plasma drug concentration; AUC0-24h: area under the concentration-time curve from time 0 to 24h.
