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Process of AAV-mediated gene vector transduction
In liver fibrosis, AAV-mediated genes, miRNA, miRNA TuDs, circRNA, or shRNA are taken into the endosome within liver cells by endocytosis. Once they enter the nucleus, AAVs uncoat and release their single-stranded genome (ssDNA), which subsequently is converted into a double-stranded DNA (dsDNA) template; thus, the transgenic gene can be transcribed and translated from the template.
