Skip to main content
. 2022 Jun 22;29:176–188. doi: 10.1016/j.omtn.2022.06.010

Figure 6.

Figure 6

In vivo target knockdown in the liver at four different time points (day 7, 21, 28, and 42)

C57BL/6JBomTac female mice (n = 5/group) are singly dosed with 1 mg/kg by intravenous administration. Animals were sacrificed at (A) day 7, (B) day 21, (C) day 28, and (D) day 42. Livers were harvested, and reduction of target ApoB mRNA in the liver was quantified by qRT-PCR relative to GAPDH. One animal in cohort RTR28253/day 28 had to be anesthetized due to exaggerated pharmacology. Statistically significant (one-way ANOVA) data are indicated. ∗∗p < 0.01; ∗∗∗p < 0.001.