Figure 8.
Metabolite formation in liver and kidney after 7 days of drug administration
C57BL/6JBomTac female mice (n = 5/group) are singly dosed with 1 mg/kg by intravenous administration. Liver and kidney were sampled at day 7. The data were measured by LC-MS/MS. Color codes represent the fragmented metabolites. RTR3833: 5′-GCatggtatTCA-3′ ASO-6: 5′-GCatggtatTCA-3′. RTR28253: 5′-GCatggtatTCA-3′. ASO-26: 5′-GCatggtatTCA-3′. Upper case designates LNA nucleotide, lower case designates DNA nucleotide, and symbols designate R configuration (red ˄), S-configuration (green ˅), PS2 linkage ( o), and phosphorothioate linkage (•).