FIG. 2.

Comparison of the amino acid sequence of E. coli K-12 GusA (top) with the deduced amino acid sequence of L. gasseri ADH GusA (bottom). Identical residues are indicated by an asterisk, conserved residues by a colon, and semiconserved residues by a dot. The three residues corresponding to human β-glucuronidase, Glu⁵⁴⁰, Glu⁴⁵¹, and Tyr⁵⁰⁴, are indicated by bold type (see the text). The amino acid residues corresponding to the PROSITE glycosyl hydrolase family 2 signature sequences are indicated by boxes. † indicates a residue that differs from the currently proposed signature sequence.