Table 2.
miRNAs involved in HCV infection, liver disease, and HCC.
| miRNAs | Viral & Cellular Targets | Mechanism |
|---|---|---|
| miR-196 67 | NS5A; Bach1 | Annealing between host protein and viral RNA |
| miR-448 5 | Core | NR |
| miR-29 67 | Collagen and ECM protein | NR |
| miR-296, miR-351, miR-431 5 | NR | NR |
| miR-130a 63 | IFITM1 | NR |
| miR-373 83 | JAK and IRF9 | Impairs JAK/STAT pathway |
| miR-124 84 | ROCK2 and EZH2 | Cytoskeletal modification and EMT |
| miR-155 85 | Wnt signaling | Inhibits apoptosis and promotes proliferation |
| miR-221/222 86 | Tumor suppressor p27, p57 and PTEN | Fibrosis progression and carcinogenesis |
| miR-199a-3p15,65 | HCV IRES-Domain II | Inhibits HCV replication |
| miR-449a 87 | NOTCH signaling & C-C ligand 2 activity | Altered expression of protein regulator (YKL40), fibrosis development |
| miR-107 87 | C-C ligand 2 activity | Promote inflammation and fibrosis. |
| miR-21 88 | SMAD7 | Fibrosis development (HSCs) via TGF-β signaling |
| miR-200c 89 | FAP1 and Src signaling | Increased expression of collagen and fibroblast factor |