Table 4.

Enzyme levels after the administration of amikacin and buprenorphine by manually and by AID.

S.No	Parameter	Amikacin				Buprenorphine
		Manual		AID		Manual		AID
		Before	After	Before	After	Before	After	Before	After
1	AST (IU/L)	39.83 ± 3.52	36.33 ± 9.59	43.83 ± 4.97	53.50 ± 10.23	42.17 ± 4.36	41.33 ± 3.73	40.52 ± 7.09	59.67 ± 10.84
		F = 0.314; p = 0.588				F = 1.584; p = 0.237
2	ALT (IU/L)	44.50 ± 4.14	41.50 ± 4.47	32.22 ± 2.76	48.50 ± 5.65a	47.07 ± 3.88	47.17 ± 3.95	31.40 ± 7.50	52.50 ± 5.70
		F = 5.605; p = 0.039				F = 2.431; p = 0.150
3	ALP (IU/L)	59.30 ± 3.83	56.05 ± 7.76	65.52 ± 3.27	61.85 ± 10.98	54.08 ± 3.03	42.17 ± 4.79	59.28 ± 3.53	40.62 ± 5.96a
		F = 0.241; p = 0.634				F = 7.019; p = 0.024
4	GGT (IU/L)	8.70 ± 0.92	8.17 ± 0.60	7.58 ± 0.88	7.32 ± 0.37	8.78 ± 1.01	8.82 ± 0.45	6.98 ± 1.24	7.48 ± 0.50
		F = 0.389; p = 0.547				F = 0.105; p = 0.752

Mean ± SE (n = 6 each).

^aSignificantly different from the respective before administration.

AID, autoinjector device; SE, standard error.