Table 1.
Clinical side effects associated with the more commonly used monoclonal antibodies.
| Monoclonal Antibody | Trade Name | Product's Type | Hypersensitivity | Immunogenicity | Immunosuppression | Infusion Reactions | Infections | Anemia | Cytopenia | Autoimmunity | Coagulation Disorders | Heart Failure | Malignancy | Others |
| Infliximab | Remicade | Chimeric | + | + | + | + | + | + | + | + | + | Increased Liver Enzymes | ||
| Basiliximab | Simulect | Chimeric | +++ | +++ | + | + | + | Skin Rash | ||||||
| Rituximab | Rituxan | Chimeric | + | + | +++ | Hypotension & Serum Sckness | ||||||||
| Cetuximab) | Erbitux | Chimeric | + | +++ | Urticaria & Bronchospasm | |||||||||
| Abciximab | ReoPro | Chimeric Fragment (Fab) | + | + | + | + | Bleeding | |||||||
| Adalimumab | Humira | Fully Human | + | + | + | + | + | + | + | + | + | Increased Liver Enzymes | ||
| Panitumumab | Vectibix | Fully human | + | + | Skin Rash & Diarrheae | |||||||||
| Alemtuzumab | Campath | Humanized | + | + | + | + | + | Thyroid Disorders | ||||||
| Daclizumab | Zenapax | Humanized | +++ | +++ | + | + | + | Cytokine Release Syndrome | ||||||
| Bevacizumab | Avastin | Humanized | + | + | + | + | Slow Wound Healing | |||||||
| Eculizumab | Soliris | Humanized | + | + | Meningitis | |||||||||
| Efalizumab | Raptiva | Humanized | + | +++ | + | + | Encephalitis | |||||||
| Natalizumab | Tysabri | Humanized | + | + | + | Hepatotoxicity | ||||||||
| Omalizumab | Xolair | Humanized | + | + | + | Injection Site Reactions | ||||||||
| Palivizumab | Synagis | Humanized | + | Apnea & Fever | ||||||||||
| Trastuzumab | Herceptin | Humanized | + | + | Skin Reactions & Cardiotoxicity | |||||||||
| Tocilizumab | Actemra | Humanized | + | +++ | + | Anaphylais & Headache | ||||||||
| Ranibizumab | Lucentis | Humanized Fragment (Fab) | + | Ocular Inflammation | ||||||||||
| Muromonab | CD3 | Mouse | + | + | + | + | Hepatitis | |||||||
| Certolizumab | Cimzia | Pegylated Humanized | + | + | + | + | + | + | + | + | + | Increased Liver Enzymes |