Summary of findings 2. Brochure and an audiotape compared with standard care for prenatal education for congenital toxoplasmosis.
| Brochure and an audiotape compared with standard care for prenatal education for congenital toxoplasmosis | ||||||
| Patient or population: women of reproductive age, irrespective of their pregnant status Settings: France Intervention: brochure and an audiotape Comparison: standard care | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Standard care | brochure and an audiotape | |||||
| Rate of toxoplasmosis seroconversion in pregnant women | Study population | RR 1.70 (0.56 to 5.21) | 3949 (1 RCT) | ⊕⊕⊝⊝ LOW 1,2 | ||
| 3 per 1000 | 5 per 1000 (2 to 15) | |||||
| Pregnant women behavior with respect to the avoidance of risk factors for toxoplasmosis infection during pregnancy (no consumption of uncooked meat of any type) | OR 1.21 (0.98 to 1.50) | (1 RCT) | ⊕⊕⊕⊝ MODERATE 1 | Events were not available for these two outcomes. OR for these two outcomes were obtained from a review that included this study. | ||
| Pregnant women behavior with respect to the avoidance of risk factors for toxoplasmosis during pregnancy (hand washing after contact with transmission factor and before meals) | OR 1.01 (0.38 to 1.22) | (1 RCT) | ⊕⊕⊝⊝ LOW 1,2 | |||
| Rate of congenital toxoplasmosis defined by persistence of IgG antibodies beyond 11 months | None of these outcomes were reported in the included study. If in future updates data on these outcomes are available we will include them in this SOF. | |||||
| Pregnant women knowledge of risk factors for acquiring toxoplasmosis infection as objectively measured through specific questionnaire | ||||||
| Pregnant women awareness of the importance of avoiding toxoplasmosis infection during pregnancy as objectively measured through specific questionnaire | ||||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; OR: odds ratio; RR: risk ratio | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1Evidence from one study with high risk of bias
2Wide CI crossing the line of no effect