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Recommendation for regional irradiation after neoadjuvant systemic therapy.
| Initial status | Status after neoadjuvant treatment | Surgical (pathology) status | RT indication |
|---|---|---|---|
| cN0 | cN0 | ypN0 (sn) | No RT |
| cN0 | cN0 | ypN1 (sn) | ABD ± RT or RT |
| cN1 (f), pN1 (sn) | cN0-1 | ypN0 | No RT |
| cN1, pN1 (sn) | cN1 | ypN1-2–3 | RT |
| cN2 (f) | cN0 | ypN0 | RT or OBS |
