Table 2.
Details of CNS Dissemination
| Patient | CNS Symptoms | Brain MRI Findings | CSF Studies (WBC Cell/µL, Glucose mg/dL, Protein mg/dL) | CSF Blastomyces Antigen (ng/mL) |
|---|---|---|---|---|
| 1 | Headache, nausea, vomiting | Normal | WBC 1, glucose 79, protein 12 | 0.28 |
| 2 | Encephalopathy | Normal | WBC 242 (94% PMNs), glucose 106, protein 190 | Not done |
| 4 | Headache, nausea, vomiting, gait disturbance | Enhancing lesion in cerebellum | WBC 2410 (93% lymphocytes), glucose 47, protein 226 | Not done |
| 7 | Encephalopathy | Diffuse punctate lesions | WBC 73 (97% lymphocytes), glucose 97, protein 266 | Negative |
| 9 | None | Normal | WBC <1, glucose 102, protein 17 | Positive below quantification |
| 11 | Headache, cranial nerve 6 palsy diplopia | Posterior Nasopharyngeal mass extending through clivus involving cavernous sinus | WBC 4, glucose 71, protein 30 | Negative |
| 12 | None | Enhancing lesions in occipital lobe and peritonsillar region | None | None |
Abbreviations: CNS, central nervous system; CSF, cerebral spinal fluid; MRI, magnetic resonance imaging; PMN, polymorphonuclear leukocytes; WBC, white blood cell count.