Table 3.
Treatment Durations of Patients With Blastomycosis
| Patient | Duration of Therapy (Days) | ISA Indication | Outcome | ||||
|---|---|---|---|---|---|---|---|
| LAMB | ISA | ITRA | VORI | Total | |||
| 1 | 21 | 219 | 0 | 28 | 268 | ADE (VORI: elevated liver enzymes, nausea, vomiting) | Ongoing antigen positivity, moved out of state |
| 2 | 46 | 61 | 0 | 36 | 143 | ADE (VORI: CNS toxicity) | Death unrelated (hemorrhagic stroke) |
| 3 | 0 | 31 | 186 | 0 | 217 | ADE (ITRA: hypertension, bradycardia) | Cure |
| 4 | 7 | 318 | 0 | 175 | 500 | ADE (VORI: rash, myalgia) | Cure |
| 5 | 9 | 270 | 120 | 0 | 399 | Subtherapeutic ITRA, ADE (POSA: drug fever) | Cure |
| 6 | 30 | 379 | 6 | 0 | 415 | Prolonged QT, ADE (ITRA: nausea, vomiting) | Cure |
| 7 | 28; 7 | 430 | 16 | 413 | 859 | DDI (VORI and Rifampin) | Ongoing antigen positivity, continued on ISA |
| 8 | 0 | 193 | 0 | 0 | 193 | Prolonged QT, heart failure | Cure |
| 9 | 14 | 241 | 4 | 119 | 378 | ADE (VORI: peripheral neuropathy) | Cure |
| 10 | 7 | 374 | 2 | 0 | 383 | ADE (ITRA: nausea, vomiting) | Cure |
| 11 | 7 | 203 | 61 | 174 | 445 | Subtherapeutic VORI | Cure |
| 12 | 19 | 298 | 0 | 61 | 378 | ADE (VORI: CNS toxicity) | Cure |
| 13 | 0 | 151 | 6 | 64 | 221 | ADE (ITRA/VORI: nausea, vomiting) | Cure |
| 14 | 13; 14 | 385 | 29 | 0 | 414 | Prolonged QT, progression on ITRA, DDI (Warfarin) | Cure |
Abbreviations: ADE, adverse drug effect; DDI, drug-drug interaction; ISA, isavuconazonium sulphate; ITRA, itraconazole; POSA, posaconazole; LAMB, liposomal amphotericin B; VORI, voriconazole.