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. Author manuscript; available in PMC: 2022 Jul 11.
Published in final edited form as: ACS Nano. 2018 Jul 6;12(7):6597–6611. doi: 10.1021/acsnano.8b01424

Figure 5.

Figure 5.

T1 contrast MR imaging by systematic and site-selective delivery of TNPs in a CRLM rat model. Monitoring in vivo T1-weighted MR images of rats with CRLM tumor for (A) pre- (0 h), post-4 h, and post-24 h tail vein injection and (B) pre- and post-5 min portal vein injection of TNP. Tumor is shown in the white outline. (C) Tumor-to-background ratio enhancement comparison of CRLM tumors between tail vein injection and portal vein injection (n = 3, *p < 0.05).