Table 1.
TMRCA estimates of distinct clades and associated subtypes of the TBEV phylogeny extracted from the TBEV Nextstrain data set (all dates are given as year CE).
| Clade | Subtype | TMRCA | Confidence interval | First isolation |
|---|---|---|---|---|
| Siberian | TBEV-Sib | 452 | 121–703 | 1963 |
| Far-Eastern | TBEV-FE | 1416 | 1287–1512 | 1937 |
| Himalayan | TBEV-Him | 1971 | 1960–1985 | 2013 |
| Strain 178–79 | TBEV-Bkl-1 | 773 | 493–961 | 1979 |
| East-Siberian/Baikalean/886-84-like | TBEV-Bkl-2 | 1933 | 1917–1947 | 1984 |
| European | TBEV-Eur | 1744 | 1703–1786 | 1951 |
| Western European | TBEV-Eur | 1973 | 1962–1987 | 2015 |
| Strain N5–17 | TBEV-Eur | 576 | 274–809 | 2017 |