Table 3.

Time Dependent Independent Predictors of Survival Using Univariate and Multivariate Cox Regression Analysis (n=90)

Predictor	Univariate OR (95% CI)	Column1 p value	Multivariate OR (95% CI)	Column2 p value
Age (yrs)
≤ 45	Ref		Ref
> 45	0.91 (0.60-1.38)	0.667	0.85 (0.51-1.41)	0.518
Gender
Female	Ref		Ref
Male	1.13 (0.62-2.08)	0.69	1.11 (0.55-2.23)	0.777
Tobacco
No	Ref		Ref
Yes	0.95 (0.59-1.56)	0.851	0.78 (0.45-1.34)	0.365
Alcohol
No	Ref		Ref
Yes	1.41 (0.93-2.15)	0.108	1.40 (0.86-2.29)	0.176
Tumor Size
T1 + T2	Ref		Ref
T3 + T4	1.37 (0.84-2.21)	0.205	1.59 (0.80-3.15)	0.185
Lymph Node Status
N0	Ref		Ref
N1 + N2	1.58 (0.69-3.62)	0.28	3.09 (1.19-7.96)	0.020*
Stage
III	Ref		Ref
IV	1.48 (0.97-2.27)	0.069	1.20 (0.65-2.24)	0.564
Grade
WD	Ref		Ref
MD + PD	1.98 (1.26-3.12)	0.003*	2.25 (1.27-4.00)	0.006*
ALDH1
Low	Ref		Ref
High	1.43 (0.87-2.35)	0.158	0.91 (0.43-1.94)	0.81
Response
CR + PR	Ref		Ref
NR	1.43 (0.94-2.16)	0.093	1.33 (0.80-2.20)	0.271
Recurrence
No	Ref		Ref
Yes	0.93 (0.61-1.41)	0.723	0.41 (0.24-0.72)	0.002*

WD, Well Differentiated; MD, Moderately Differentiated; PD, Poorly Differentiated; CR, Complete Response or Complete Responder; PR, Partial Response or Partial Responder; NR, No Response or Non Responder; OR, Odds Ratio; CI, Confidence Interval; Ref, Reference Category. The mentioned odd ratio is evaluated against reference category; *: p<0.05