Table 2.

Results of the Outcome Surveys in the Japan Nurses' Health Study

Cancer site	Stomach		Colorectal		Liver		Lung		Thyroid
Biennial follow-up surveys (definition 1)
Eligible womena	14,984		14,984		15,016		15,010		14,981
Self-reported diagnosis = yes (potential incident cases) [% among eligible women]	72	[0.5%]	136	[0.9%]	12	[0.1%]	83	[0.6%]	99	[0.7%]
Withdraw/lost of follow-up/death	2		5		1		4		6
Proceed to the additional outcome surveys [% among potential incident cases]	70	[97.2%]	131	[96.3%]	11	[91.7%]	79	[95.2%]	93	[93.9%]
Additional outcome survey (definition 2)
Eligible women	70		131		11		79		93
Responded [%]c	64	[91.4%]	117	[89.3%]	9	[81.8%]	65	[82.3%]	76	[81.7%]
Self-reported diagnosis = yes [% among respondents]	53	[82.8%]	109	[93.2%]	8	[88.9%]	57	[87.7%]	64	[84.2%]
Self-reported diagnosis = no	9		7		1		8		11
Self-reported diagnosis = unknown	2		1		0		0		1
Agreed on the medical facility survey [% among respondents]	27	[50.9%]	49	[45.0%]	2	[25.0%]	29	[50.9%]	37	[57.8%]
Medical facility survey (definition 3)
Eligible women	27		49		2		29		37
Responded [%]c	20	[74.1%]	33	[67.3%]	0	[0.0%]	22	[75.9%]	32	[86.5%]
Physician-reported diagnosis = yes [% among respondents]	20	[100.0%]	32	[97.0%]	0	(NA)	19	[86.4%]	31	[96.9%]
Death certificate
Death from cancer during the follow-upb	7		6		2		10		2
Self-reported diagnosis at follow-up = yes	5		3		0		6		2
Death certificate only	2		3		2		4		0
Overall decision by Validation Study Committee (definition 4)
Eligible women (=potential incident cases)	72		136		12		83		99
Diagnosis = yes [% among potential cases]	58	[80.6%]	93	[68.4%]	7	[58.3%]	54	[65.1%]	64	[64.6%]
[% among all eligible women]		[0.4%]		[0.6%]		[0.05%]		[0.4%]		[0.4%]

JNHS: Japan Nurses' Health Study, NA: not applicable; ^a. Eligible women were cohort members without a self-reported diagnosis of each disease at baseline (total cohor menbers: N=15,019); ^b, As of Apr. 30, 2019; ^c, As of Jul. 31, 2019